The most alarming plastic products cannot be charg

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Alert: plastic products cannot be filled

an old friend who has not seen him for many years came to visit uncle he while traveling. Uncle he was very happy. After meeting, he sat down and exchanged greetings for a few minutes. Suddenly, he covered his chest in pain and groaned. His daughter knew that his father's angina pectoris had broken out again. She quickly took a nitroglycerin tablet from his pocket and put it under his tongue. A few minutes later, the pain did not abate, and another tablet was still invalid. Looking at uncle he's painful expression, everyone panicked and rushed to the hospital for first aid before turning the corner. Later, uncle he felt puzzled that the effect of taking medicine was good at ordinary times, but it didn't work this time. Could it be that the plane painting of his illness had been unable to satisfy his curiosity about these faces. He took the medicine and asked the doctor. The doctor found that the tablets were loose and adhesive. The tablets were packed in a plastic film bag for monosodium glutamate, while the nitroglycerin tablets were usually packed in brown glass. His daughter explained that in order to make it easy to take medicine and carry them around, the tablets were changed into simple packaging a month ago. I see. The doctor found out that it was probably the plastic bags that caused the trouble. Plastic film bags do not block light, do not avoid heat and moisture, and plastic has an adsorption effect on nitroglycerin. Over time, accelerating the lack of competitive capacity and quitting nitroglycerin tablets will fail, which almost led to a big mistake

generally speaking, the interaction of drugs in vivo often leads to the enhancement of toxicity or the reduction or even failure of efficacy of some drugs, while the result of the interaction between drugs and some substances in vitro such as packaging is mainly to reduce the bioavailability or efficacy of drugs. Some plastic products have obvious adsorption on some drugs, thereby reducing the effective concentration of drugs, which has been confirmed in clinical practice. It is known that plastics can produce clinically significant adsorption on the following drugs: diazepam, insulin, diazepam, nitroglycerin, nitroisosorbitol, acetate, warfarin sodium, hydrazine hydrochloride and thiopental sodium, as well as some antihistamines, phenothiazines, etc. The adsorption rate of nitroglycerin is as high as 80%. It is reported that some drugs can also react with syringes. For example, adriamycin hydrochloride reacts with the injection needle, causing precipitation or discoloration. Etoposide and aminophenidate can react with disposable plastic syringes. Therefore, syringes should sometimes be selected according to the nature of the injection to avoid adverse interactions. There are also some Chinese herbal medicine solutions in plastic bottles, which are easy to deteriorate and lose efficacy after being stored for a long time

at present, most of the plastic medicine bottles on the market are high-density polyethylene plastic products, which have great air permeability, moisture permeability and light transmittance, so the drugs in the bottles can not be completely isolated from the external air, moisture and light, and there is still a large distance between the source and heat source, so that the drugs are vulnerable to the influence of these factors and are gradually decomposed, destroyed or corrupted. If people take this kind of liquid medicine, it will not only be useless, but will aggravate the disease. If the neutral glass bottle is used to contain the liquid medicine, there will be no rancidity, precipitation, dampness and loss of liquid medicine capacity. This unit has the function of automatic zero adjustment, especially the brown glass bottle, which has a good effect of avoiding light, and is especially suitable for containing drugs that are easy to decompose due to light (such as phenol, suprarenal adenosine, quinolone antibiotics, vitamins A, D, B12, reserpine, iodoform, hydrogen peroxide, etc.). Propolis solvent generally contains alcohol, which is easy to react with plastic and produce harmful substances, which is harmful to human health. It is best to use glass containers. In wet seasons, drugs are easy to be affected by moisture and deteriorate, so after the use of drugs, try to restore the original packaging and put the drugs in a closed state. Avoid using paper bags, cartons, plastic bags and other non moisture-proof packaging materials

source: China packaging business

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